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A healthy cholesterol level is an important part of heart health.‡ CholestOff Plus® is formulated with esterified sterols and stanols instead of free-form sterols and stanols that are formulated in CholestOff Original®. The esterified sterols and stanols have been clinically proven to have cholesterol-lowering benefits.‡ Additionally, Nature Made® has conducted clinical trials examining the effects of CholestOff Plus® on cholesterol. Our studies show that consuming CholestOff Plus® in addition to following the National Institutes of Health's National Cholesterol Education Program (NCEP) Therapeutic Lifestyle Changes (TLC) diet, reduced LDL cholesterol levels.‡